Research and Innovation

Dr Ram is Principal Investigator for several national and international clinical trials involving high-precision radiotherapy and combination chemotherapy and immunotherapy. He has also introduced four cancer treatments to the UK for the first time.

BOOK A CONSULTATION

Innovations

Dr Ram has introduced four cancer treatments to the UK for the first time:

First adult head and neck cancer patient in the UK treated with Low Level Laser Therapy to reduce radiation-induced oral mucositis
March 2015

First use in the UK of intra-operative radiotherapy with a mobile electron linear accelerator for recurrent rectal and gastrointestinal cancers

First implementation of PhotoBioModulation Therapy in the UK private sector to reduce radiotherapy-induced toxicity

First use of photo-medicine to treat cancer treatment-related trismus and fibrosis
May 2017

Clinical trials

Selected publications

Prospective evaluation of Next Generation Sequencing (NGS) plasma HPVDNA assay for treatment response estimation in head and neck cancer. Radiotherapy and Oncology, Vol 206: S1071–1072, May 2025.
Comparing survival and recurrence patterns in locally advanced oral cavity squamous cell carcinoma. Radiotherapy and Oncology, Vol 197, April 2025.
KEYNOTE-412 Investigators (2024). Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised double-blinded, phase 3 trial. The Lancet Oncology, Vol 25(5), p572–587.
PTCOG Gastrointestinal Subcommittee Lower Gastrointestinal Tract Malignancies Consensus Statement: Proton Therapy Indications, Treatment Delivery and Case Discussion. International Journal of Particle Therapy to Practical Radiation Oncology, Vol 11.
TORPEdO – A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer. Clinical and Translational Radiation Oncology, Vol 38, p147–154.
Therapy Options in the Management of Endolymphatic Sac Tumours: A case series and literature review. Surgical Neurology International, 22 Aug 2025; 16:349.
Photobiomodulation in the management of oral mucositis for adult head and neck cancer patients receiving irradiation: the LiTEFORM RCT. Health Technology Assessment, Vol 26, Issue 46, December 2022.

Communicating Hydrocephalus after Radiotherapy for Vestibular Schwannoma. Cureus Journal of Medical Science-9, Sep 2025.
De-escalating radiotherapy in HPV-positive oropharyngeal squamous cell carcinoma: How much is too little? BMJ Case Rep 2024;17e, 2023-257078.
Three Fraction Stereotactic Radiotherapy (SRT) for Vestibular Schwannoma: The Wessex experience. Neuro-Oncology 25(suppl_3), October 2023.
Radiotherapy dose for HPV driven oropharyngeal cancer: what is enough? British J of Surgery, Vol 108, Issue Suppl 6, 259.559, September 2021.
Nivolumab vs Investigator’s Choice in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: Efficacy and Safety in CheckMate 141 by Prior Cetuximab Use. Journal of Clinical Oncology 35, no. 15_suppl 6020–6020.
Review on the cellular mechanisms of low-level laser therapy use in oncology. Frontiers in Oncology, Vol 10, art 1225, June 2020.
Dose-Escalated Intensity-Modulated Radiotherapy in Patients with Locally-Advanced Laryngeal and Hypopharyngeal Cancers: ART-DECO, a Phase 3 Randomised Controlled Trial. European Journal of Cancer, Vol 153, p242–256.
Outcomes of radically treated locally advanced head and neck cancer patients in Southampton. Clinical Oncology, Vol 27 Suppl 1, S2–3, June 2015.

Contact Dr Ram

Dealing with cancer can be a difficult and emotionally challenging situation. Dr Ram always has your best interests and wellbeing at heart.

Make an enquiry or book an appointment today to see how Dr Ram can help.